Riza’s interest in medical optics goes back to his 1989 General Electric (GE) days with the development of simplest control liquid crystal electronic lens motivated by vision applications. Between 1995-1998, Riza’s group introduced the use of optics for phased array ultrasound controls including the concept of intracavity optical wavelength to one dimensional space mapping using an intracavity single fiber probe and spatial distribution via wavelength multiplexing. Since 1998, the group has also proposed and demonstrated several novel optical imaging systems such as the first acousto-optic design based Optical Coherence Tomography (OCT) system, Angstrom sensitivity high speed scanning interferometric imagers, fiber-based scanning imaging endoscopes, and confocal microscopes such as spectral microscopes and agile no-moving parts microscopes.